Paul Petersen, an American actor, singer, novelist, and activist, played the role of son, Jeff Stone on The Donna Reed Show.

Darryl Richard made 20 appearances on The Donna Reed Show in the role of Smitty, the best friend of Jeff Stone, played by Paul Petersen.

Mimsy Farmer guest-stars on The Donna Reed Show in three different episodes, each time playing a different one of Jeff's love interests.

Shelley Fabares is best known for her television roles as Mary Stone on the sitcom The Donna Reed Show (1958–1963).

Janet Landgard was a regular on The Donna Reed Show during Seasons 6, 7, and 8, playing the part of Karen, Jeff's girlfriend.

Patti Petersen co-starred on The Donna Reed Show. She was written into the cast as Trisha, an adopted child after Shelley Fabares left.