Bobby Burgess, an original Mouseketeer and later a regular on The Lawrence Welk Show, also made an appearance on The Donna Reed Show.

When The Donna Reed Show premiered, Campbell's Soup was the sponsor. By the fourth show, everyone was prepared for the show to be canceled.

Richard Deacon had recurring roles in television shows such as The Dick Van Dyke Show, Leave It To Beaver, and The Donna Reed Show.

Character actor Doodles Weaver appears in four episodes of The Donna Reed Show in seasons 3, 4, and 5.

Miyoshi Umeki, known for her role in the television series The Courtship of Eddie’s Father, appears in two episode of The Donna Reed Show.

Professional baseball center fielder Willie Mays appears in three episodes of The Donna Reed Show (S6, Ep31), (S7, Ep3) and (S8, Ep 20).

Lesley Gore recorded the pop hit "It's My Party" (1963). She appears in the last episode of The Donna Reed Show singing, "It's My Party."

Cloris Leachman, actress and comedienne from Des Moines, Iowa, guest-stars on The Donna Reed Show in "Mouse at Play" (S4, Ep 4).

Florence MacMichael guests in two episodes of The Donna Reed Show - "The Fatal Leap" ( S2, Ep 26) and "The Poodle Parlor” (S3, Ep 26).

Lori Martin, known for her role on National Velvet, appears on The Donna Reed Show in “All Women Are Dangerous” (Season 5 Episode 32).

Between 1959 and 1961, Tommy Ivo appeared in five episodes of The Donna Reed Show as Mary's boyfriend, Herbie Bailey.

Hans Conried (Uncle Tonoose on Make Room for Daddy) guests on The Donna Reed Show in “It’s the Principle of the Thing” ( S1, Ep18).

Harry Morgan (M*A*S*H) has more than 100 films to his credit. He appears with Donna Reed in Gentle Annie (1944) and Backlash (1956).

Roberta Shore began her career at age ten, singing country-western songs at supermarket openings with Tex Williams.

John Astin, the kooky patriarch of tv'sThe Addams Family, stars in “The Mouse at Play” (Season 4, Episode 4) of The Donna Reed Show.

Mary Treen, a popular minor actress, appears with Donna Reed in It's a Wonderful LIfe and in three episodes of The Donna Reed Show.

Johnny Crawford, known as Mark McCain in the Western series The Rifleman, appears on The Donna Reed Show in Season 4, Episode 15.

Darryl Richard is best remembered for the role of "Smitty", the best friend of the character Jeff Stone, on The Donna Reed Show.

Carl Betz is best remembered for playing Dr. Alex Stone, Donna Reed's tv husband, from 1958 to 1966 in the ABC sitcom The Donna Reed Show.

Linday Workman appears in nine episodes of The Donna Reed Show (Season 2 - Season 4) in the role of Dr. Jim Higgins, Alex Stone's colleague.